(2R)-1-[tert-butyl(dimethyl)silyl]oxypropan-2-ol

CAS No.：

Cat. No.: SC251156

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Product Name :(2R)-1-[tert-butyl(dimethyl)silyl]oxypropan-2-ol

Cat. No.: :SC251156

Purity / Specification :—

CAS No. :136918-07-5

MDL No. :NA

Molecular Formula :C₉H₂₂O₂Si

LogP :2.39

Molecular Weight :190.36

TPSA :29.5

Category :CRO / Contract Research

HSN Code :—

SMILES Code :C[C@H](CO[Si](C)(C)C(C)(C)C)O

Melting Point :—

InChI Key : :BJDDRAYUVSVPPR-MRVPVSSYSA-N

Boiling Point :No data available

Application Note

AI Generated

Generated by AI. Verify before use in regulatory documents.

Lipinski & ADMET Properties

Computational estimate

Lipinski Rule of 5

✓ PASS

MW ≤ 500 Da✓ 190.4 Da

LogP ≤ 5✓ 2.39

HBD ≤ 5✓ 1

HBA ≤ 10✓ 2

Max 1 violation allowed for oral bioavailability.

Drug-likeness Score

69/100

Moderate — typical building block

Predicted LogP

2.39log units

Optimal range (0–3)

CNS Permeability

Clark model · J Pharm Sci, 1999

CNS+ likely

TPSA 29.5Å² · Threshold: <60 CNS+ · 60–90 CNS± · >90 CNS−

Requires experimental confirmation.

⚠ These are computational estimates based on Lipinski & Veber physicochemical rules. They are not validated ADMET predictions and must not be used for clinical, regulatory, or safety decisions. For research use only.