Custom Synthesis
from Milligrams to Kilograms
FTE and Fee-for-Service models, NDA before any technical discussion, and a 24-hour feasibility response on every enquiry.
Sparge Chem runs custom synthesis programs from single-digit milligram exploratory batches through multi-kilogram scale-up, on the same lab-to-pilot infrastructure used for our own building-block catalog. Founded in 2017 by Dr. Ravindra Pal and Ankush Sarde at Bhosari MIDC, Pune, the team has scaled process routes for GMP intermediates as large as 600 kg — so a kilogram-scale custom synthesis request runs through equipment and a team that has already done it, not a lab learning to.
Two engagement models cover most requests: Fee-for-Service (FFS) for a defined target with a fixed scope and deliverable, and a dedicated FTE (Full-Time Equivalent) model where a chemist or small team works exclusively on your program over an agreed period — useful for multi-step campaigns, iterative SAR work, or when a route needs redesigning mid-project rather than re-scoping from scratch.
Every custom synthesis engagement starts the same way: an NDA is signed before any structure, route, or technical detail is discussed. We give a feasibility response — route assessment, indicative timeline, and scale-up risk flags — within 24 hours of receiving a target structure and specification.
What's included
Route scouting & selection
Literature and retrosynthetic analysis to identify 2–3 viable routes before committing lab time, weighted for step count, cost of goods, and scale-up risk.
Multi-step organic synthesis
In-house synthesis across common transformations (cross-coupling, protection/deprotection, reductive amination, heterocycle construction) without subcontracting intermediate steps.
Milligram to kilogram scale-up
The same route is developed at bench scale and then scaled through our pilot infrastructure (100L, 250L, and 500L reactors) rather than handed to a separate scale-up team, so nothing is lost in translation between the two.
Analytical support
In-house HPLC/LCMS and NMR-backed characterization at every stage, with a Certificate of Analysis issued against each batch.
GMP and non-GMP tracks
Both a GMP facility and a non-GMP facility on site, so early-stage exploratory chemistry and later regulatory-grade production can run under the appropriate quality system without switching vendors.
IP protection
NDA executed before any technical discussion; all route and structure information is treated as your confidential information by default, not shared or reused without written permission.
How it works
Share your target
Send the target structure (or SMILES/CAS if it's a known compound), required quantity, purity spec, and timeline. An NDA goes out first if one isn't already in place.
24-hour feasibility response
We assess synthetic routes, flag scale-up or supply-chain risks on any step, and come back with an indicative timeline and quote — usually within 24 hours.
Route development at bench scale
The selected route is run and optimized at small scale first, with full analytical characterization at each intermediate.
Scale-up
Once the route is validated, it moves to pilot scale (100L–500L) with the same team that developed it, minimizing the risk that scale-up introduces new impurities or yield loss.
Delivery with CoA
Final material ships with a Certificate of Analysis; NMR, LCMS, and other analytical data are available on request.
Track record
600 kg GMP scale-up, 99.5%+ purity
Sparge Chem scaled Letermovir intermediate synthesis to 600 kg in our GMP facility (and 50 kg in the non-GMP facility) at 99.5%+ purity — the same scale-up discipline available to any custom synthesis program, not a one-off.
Process development for quinoline derivatives
In-house process development work on quinoline derivative intermediates, taken from initial route through to scalable process.
Common questions
What scale can you synthesize at?
From milligram exploratory batches up to multi-kilogram GMP production — we've scaled a GMP intermediate to 600 kg in-house. The same team handles bench-scale route development and pilot-scale (100L–500L) scale-up.
Do you sign an NDA before discussing our target?
Yes — an NDA is executed before any structure, route, or technical detail is shared, as standard practice, not an optional add-on.
What's the difference between your FTE and Fee-for-Service models?
Fee-for-Service covers a defined target with a fixed scope and deliverable. FTE dedicates a chemist or small team to your program exclusively over an agreed period — better suited to multi-step campaigns or iterative work where the scope may evolve.
How fast do you respond with a feasibility assessment?
Within 24 hours of receiving a target structure and specification, including an indicative timeline and any scale-up risk flags.
Ready to discuss custom synthesis?
NDA before any technical discussion. 24-hour feasibility response.